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Depression - Recent Trends in Research
1.  Of the major types of depressions, which is the least severe?
A) major depression
B) dysthymia
C) unipolar depression
D) bipolar disorder
2.  About what percentage of Americans have a depressive disorder in any given year?
A) 10%
B) 15%
C) 25%
D) 35%
3.  Research has repeatedly shown that the best treatment for people diagnosed with a major depression is:
A) Keeping the patient away from all unwanted social activities.
B) Medication.
C) Lengthy vacations with plenty of rest.
D) Medication and "talking therapies."
4.  Research has shown that ________is essential for maintaining good mental health.
A) a moderately optimistic illusion
B) a realistic appraisal of one's choices
C) a sound financial basis
D) marriage
5.  The same area of the brain is activated by optimism and depression.
A) True
B) False
6.  When data on over 14,000 paticipants was re-analayzedin 2009,
A) the seretonin transporter gene showed a relationship to risk of depression
B) incorporating environmental exposures yield false positives as often as the gene studies.
C) gene analysis was found to have a major positive effect.
D) environmental impact was found to have a major positive effect.
7.  Research by Jing Du of NIMH suggests that
A) long-term stress boosts cortisol and is critical in building resistance to stress.
B) elevated levels of glucocorticoids consistently enhance cell functioning.
C) corticosterone provides energy for acting quickly in an emergency.
D) chronic stress does not lead to chronically elevated glucocorticoids.
8.  Specific variations in genes have been shown to regulate depression and
A) the serotonin system.
B) protection from the depression-promoting variations.
C) no genes have been found that are specifically related to depression.
D) overrides the positive effects of 5-HTTLPR "S" version.
9.  Some types of depression run in families.
A) It is a false belief that depression runs in families.
B) activity decreased or remained unchainged when families with a predisposition to depression are given a drug that depletes dopamine and norepinephrine.
C) brain chemicals dopamine and norepinephrine appear associated with depression.
D) Members of these families are unable to feel pleasure.
10.  People who are prone to depression
A) show evidence that environment alters DNA.
B) indicate that epigenetics plays a major role.
C) have shown that stress consistently precipitates onset of illness.
D) show genetic mutation.
11.  All depressed patients respond positively to
A) psychotherapy
B) medication
C) psychotherapy and medication.
D) not all patients respond to treatment.
12.  Research has suggested that early maternal care affects
A) the methylation state of specific genes..
B) hormonal response to stress.
C) the DNA chromatin structure
D) All of the above.
13.  Suicidal events may be predicted by
A) suicidal thinking, higher levels of parent-child conflict, and the use of drugs or alcohol.
B) CBT
C) the use of combination therapies.
D) non-suicidal self injury.
14.  Suicidal behavior
A) can be predicted by the prevalence of suicidal thoughts.
B) can be predicted by non-suicidal self injury.
C) tend to happen early in the treatment process
D) can be stopped with quick, decisive treatment.
15.  Anti-anxiety medications such as benzodiazepines
A) increase the liklihood of a suicidal event in research by Brent.
B) decrease the liklihood of a suicidal event in research by Brent.
C) have consistently shown they have no effect on suicidal events.
D) should always be used with a SSRI.
16.  Successful treatment of persistent depression
A) can be helped by several treatment strategies.
B) is not likely to be responsive to other treatments if medication fails to help.
C) is not likely to be responsive to other treatments if CBT does not help.
D) shows improved odds of success as more treatment strategies are tried.
17.  If a first treatment with an SSRI fails
A) no other SSRI will be effective.
B) the patient should be tried on a different SSRI.
C) the patient should be given benzodiazapines to increase success.
D) it should be continued until it is effective.
18.  Diligent follow-up after initial success
A) is unnecessary once the medication has begun to be effective.
B) is necessary so medications can be stopped once the depression has passed.
C) is essential to avoiding relapse in teen depression.
D) increases the liklihood of future depressive episodes.
19.  The use of SSRI's during pregnancy
A) may result in problems in the fetus such as breathing.
B) increase the risk of premature births.
C) greatly increase the risk of major birth defects.
D) increases the risk of low birth weight more than untreated major depression.
20.  People who experience high levels of anxiety with a major depression
A) have more severe depression than those with depression alone.
B) are more likely to be unemployed.
C) are less likely to respond to anti-depressants
D) All of the above.
21.  Overall analysis of the STAR*D results indicates
A) if an SSRI fails people should switch to medication of a different class since SSRIs are not effective for that person.
B) if an SSRI fails, a different SSRI may be as effective as a different class of medication
C) adding an additional medication is not useful in treating resistant depressions.
D) patients who become symptom-free have no better chance of remaining well than those who experience only symptom improvement.
22.  Selecting the optimal treatment for teens
A) is not possible since moderators of treatment response are not yet known.
B) requires that CBT be used along with medication.
C) is crucial for those who do not respond to an initial treatment.
D) is based on their initial diagnosis.
23.  Combining psychotherapy with medication in long-term studies of depressed teenagers.
A) generally is more expensive due to investment in long-term therapy.
B) can be cost-effective.
C) shows no significant improvement in outcome studies.
D) shows no improvement over switching to an SNRI.
24.  The liklihood of depression following an acute stroke can be reduced with psychotherapy and medication.
A) True
B) a stroke causes depression through specific chemical changes.
C) little is known about this phenomona.
D) a stroke directly effects thickening of the brain tissues, thus causing depression.

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